Our clients Manufacturing Sciences and Technology (MSAT) Upstream Group is looking for a highly motivated and versatile candidate to join their multidisciplinary team of scientists and engineers in Andover, MA. MSAT supports a portfolio of late-stage development of commercial biopharmaceuticals and vaccines, and is responsible for process troubleshooting, process improvements and second- generation process development. We are looking for someone who is eager to contribute independent thinking and technical excellence to the upstream fermentation team. The Scientist will be a part of a diverse and motivated team of scientists, engineers, and technical professionals that are focused on fermentation processes to produce biotherapeutics. The role is well-integrated into the rest of the MSAT Microbial Team. This role will collaborate with other MSAT scientists to setup bioreactors and execute well-designed experiments, including but not limited to basic analytics, data acquisition and documentation of work. The candidate would also be responsible for user-level maintenance of the relevant equipment and associated documentation.
Plan and execute upstream process experiments at benchtop scales
Participates and significantly contributes to discussions in lab and project team meetings on design of experiments (bioreactor and shake flask) and interpretation of experimental data.
Acts as a technical resource within the upstream group. Provides formal/informal mentoring to junior colleagues within work group/project team.
Works under limited supervision with periodic review of achievement of results and experimental approaches employed. Manages own time to meet agreed targets. Develops plans for short-term work activities on own projects.
Ensures effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks and internal technical reports; presents data/ strategy to scientists and management in appropriate internal and external venues (technical meetings, project team meetings, conferences) as appropriate.
Contributes to safe, efficient, effective and harmonious lab environment, ensures appropriate cleanliness and status/ operability of shared or assigned lab space or equipment; strong lab citizen and collaborative team player; approaches the job with energy and commitment; frequently demonstrates initiative.
Participate in multi-disciplinary teams to resolve complex issues
Assist in manufacturing investigations and process troubleshooting
Assist on process improvement projects
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Ph. D. with 0-4 years of experience in biotechnology Masters degree in a relevant discipline with at 3-5 years of applicable bioprocess experience or bachelors degree with at least 7 years of experience
Proficient in aseptic technique
Proficient in benchtop bioreactor operation and associated analytical tools
o An in-depth knowledge of bioreactor operations fed-batch, perfusion, and continuous modes of cell culture
Experience with bench scale cell culture and/or bacterial fermentation (required)
Ability to troubleshoot technical issues, plan and carry out experiments independently, and work with complex instrumentation and software.
Prior experience developing and maintaining scale down models of commercial biopharmaceutical processes
Prior experience in developing commercially relevant cell culture processes to produce pharmacologically active proteins.
Knowledge of all aspects of cell culture/fermentation, including batch, fed-batch, perfusion and harvest/clarification operations
Experience with control and data acquisition systems
Familiarity with DoE and other statistical tools
Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.